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The Caldera 6" x 10" Instant Cold Pain Relief Pack is a single use disposable product. Squeeze to activate, no refrigeration is needed. Instant Cold Pain Relief Pack is ideal for sore muscles, aching joints, sprains and strains, and insect bites. Store your instant cold packs in a first aid kit, car, boat, gym bag, backpack, or training room. Caldera International, Inc. offers innovative therapy products that provide relief for muscles and joints that are aching or sore due to sports-related injuries, post-workout fatigue, surgery and various other applications.